Additive vasospasm; risk of hypertension. Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate . Monitor for hypertension with concomitant use. only. Monitor BP. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Other (see comment). Contraindicated. Other (see comment). molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. These cannot be substituted on a milligram-per-milligram basis. Monitor BP. Monitor BP. Risk of acute hypertensive episode. Serious - Use Alternative (1)dihydroergotamine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Risk of acute hypertensive episode. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Contraindicated (1)rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor BP. Minor/Significance Unknown. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Mechanism: pharmacodynamic synergism. This drug is available at a higher level co-pay. Serious - Use Alternative (1)ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Mechanism: pharmacodynamic synergism. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. However, the dose is usually not more than 60 mg per day. Either increases effects of the other by pharmacodynamic synergism. Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Additive pressor effect. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Use Caution/Monitor. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Other (see comment). Monitor BP. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. However, Ritalin is a short-acting stimulant that boosts focus and attention quickly. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Use Caution/Monitor. Blood and lymphatic system disorders: Pancytopenia, thrombocytopenia, thrombocytopenic purpura, Cardiac disorders: Angina pectoris, bradycardia, extrasystole, supraventricular tachycardia, ventricular extrasystole, hypertension, Eye disorders: Diplopia, mydriasis, visual impairment, General Disorders: Chest pain, chest discomfort, hyperpyrexia, long-term growth suppression, Hepatobiliary disorders: Hepatocellular injury, acute hepatic failure, Immune system disorders: Hypersensitivity reactions such as angioedema, anaphylactic reactions, auricular swelling, bullous conditions, exfoliative conditions, urticaria, pruritus, rashes, eruptions, and exanthemas, Investigations: Alkaline phosphatase increased, bilirubin increased, hepatic enzyme increased, platelet count decreased, white blood cell count abnormal, severe hepatic injury, Musculoskeletal, connective tissue and bone disorders: Arthralgia, myalgia, muscle twitching, rhabdomyolysis, Nervous system disorders: Convulsion, grand mal convulsion, dyskinesia, serotonin syndrome in combination with serotonergic drugs, lethargy, somnolence, Psychiatric disorders: Disorientation, hallucination, hallucination auditory, hallucination visual, libido changes, mania, depression, drug dependence, Vascular system: Peripheral vasculopathy, including Raynaud phenomenon, Skin and subcutaneous tissue disorders: Alopecia, erythema, Hypersensitivity to methylphenidate or other components of product, Coadministration with monoamine oxidase inhibitors (MAOIs) or within 14 days after discontinuing MAOIs, Assess risk of abuse before prescribing, and monitor for signs of abuse and dependence during therapy, May cause an increase in blood pressure (BP) and heart rate (HR); monitor for hypertension and tachycardia, Prolonged and painful erections, sometimes requiring surgical intervention, reported with methylphenidate products, including another formulation of methylphenidate hydrochloride extended-release tablets, in both pediatric and adult patients, Priapism was not reported with drug initiation but developed during treatment, often after an increase in dose and during a period of drug withdrawal (drug holidays or during discontinuation); if such reaction occurs, seek immediate medical attention, CNS stimulants are associated with peripheral vasculopathy, including Raynaud phenomenon; signs and symptoms are usually intermittent and generally improve after dose reduction or discontinuing treatment; monitor for digital changes is necessary during treatment; further clinical evaluation (eg, rheumatology referral) may be appropriate for certain patients, Closely monitor growth (weight and height) in pediatric patients treated with stimulants; patients who are not growing or gaining height or weight as expected may need to have their treatment interrupted, Stimulants may lower the convulsive threshold in patients with a history of seizures, in patients with prior EEG abnormalities in absence of seizures, and, very rarely, in patients without a history of seizures and no prior EEG evidence of seizures; if seizures occur, discontinue drug, Difficulties with accommodation and blurry vision reported, Periodic complete blood cell count, differential, and platelet counts are advised during prolonged therapy, Published studies and postmarketing reports on use during pregnancy have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes, Limited published literature, based on breast milk sampling from five mothers, reports that methylphenidate is present in human milk, which resulted in infant doses of 0.16% to 0.7% of the maternal weight-adjusted dosage and a milk/plasma ratio ranging between 1.1 and 2.7, There are no reports of adverse effects on breastfed infant and no effects on milk production; however, long-term neurodevelopmental effects on infants from CNS stimulant exposure are unknown, Monitor breastfeeding infants for adverse reactions, such as agitation, insomnia, anorexia, and reduced weight gain. Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Monitor Closely (1)doxepin, methylphenidate. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Monitor Closely (1)thioridazine, methylphenidate. omeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)apomorphine, methylphenidate. Monitor Closely (1)haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Use Caution/Monitor. Potential for additive CNS stimulation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Mechanism: unknown. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. dihydroergotamine intranasal, methylphenidate. Use Caution/Monitor. Monitor Closely (1)desipramine, methylphenidate. Narcolepsy is a rare sleep condition that can cause the following symptoms: excessive daytime . Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (2)perphenazine, methylphenidate. May change the dose or how often you use one or both the... 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